Myocardial Infarct Scar

Ventricular tachycardia associated with myocardial infarct scar: a spectrum of therapies for a single patient.

Case: A 73-year-old woman is referred for management of recurrent ventricular tachycardia (VT). She had suffered an inferior wall myocardial infarction in 1970. Fifteen years later, she presented with a wide QRS tachycardia, palpitations, and dizziness. Therapy with amiodarone was initiated but discontinued in 1997 because of toxicity, and she received an implantable cardioverterdefibrillator (...

Growth Hormone–Releasing Hormone Agonists Reduce Myocardial Infarct Scar in Swine With Subacute Ischemic Cardiomyopathy

BACKGROUND Growth hormone-releasing hormone agonists (GHRH-As) stimulate cardiac repair following myocardial infarction (MI) in rats through the activation of the GHRH signaling pathway within the heart. We tested the hypothesis that the administration of GHRH-As prevents ventricular remodeling in a swine subacute MI model. METHODS AND RESULTS Twelve female Yorkshire swine (25 to 30 kg) under...

Dose-dependent effects of short-term methylprednisolone on myocardial infarct extent, scar formation, and ventricular function.

Myocardial Infarct Quantification

Radionuclide techniques for sizing acute myocardial infarction have been hampered by the intrinsic limitations of the scintillation camera. Emission computed tomography can overcome these limitations. Single photon emission computed tomograms of the distribution of technetium-99m pyrophosphate in acute anterior and posterior infarcts were obtained in 16 dogs after death. Tomograms were also obt...

Measuring myocardial scar by CMR.

c r o “ e m s d r w n Late gadolinium enhancement (LGE) using cardiac magnetic resonance (CMR) has emerged as the gold-standard technique for imaging of myocardial scar. The basic principle is inversion-recovery imaging after a 5to 10-min delay following intravenous administration of gadolinium contrast (1). With appropriate settings, normal myocardium appears nulled or black, whereas nonviable...